Toxocara canis (T.canis) is an important parasite that infects many domestic and farm animals whose economical importance cannot be neglected. The aim of the present study is to detect the hematological, biochemical and histopathological changes on kidney of rats vaccinated with two doses of gamma radiation (600Gy and 800Gy)embryonated eggs. Eighty rats were divided into four groups group I: as normal control group (-ve control), group II: received 2500 infective embryonated T. canis eggs per ml/rat orally, as control infected (+ve control), group III:  received 600 Gy irradiated T.canis eggs, group IV:  received 800 Gy irradiated T. canis eggs, However, at 14^th day post infection, rats were re-infected (challenged) with non-irradiated infective T.canis eggs. The study showed marked histopathological changes with significant decrease of glutathione (GSH) and superoxide dismutase (SOD) and remarkable increase of lipid peroxidation (MDA) in kidney tissue of infected control group. Also, marked increase in urea, creatinine and total proteins with decrease in albumin in control infected group. Vaccinated-challenged group III and IV showed amelioration in all histopathological, biochemical and hematological changes. Radiation exposure attenuated the larval migration from the gastrointestinal tract to other organs and controls the damaging effect on the kidney. The dose of 800Gy showed better results than lower dose.