The present study was undertaken to assess and compare the hematology and serum biochemical parameters of cats experimentally infected with Toxocara cati (infected group) and healthy cats (control group). A total of fourteen and six blood samples were collected from infected and control groups respectively. Hematological changes showed a significant decrease of Hemoglobin concentration (Hb), Total Erythrocytes Count (TRBCs), Packed Cell Volume (PCV), and Platelets Count (Pt), furthermore a significant increase in Mean Corpuscular Volume (MCV) and significant decrease in Mean Corpuscular Hemoglobin Concentration (MCHC) which reflects a macrocytic hypochromic type of anemia is present. Results also revealed a significant increase in Total Leukocytes Count (TWBCs) due to significant increase of neutrophils and eosinophils. The results of serum biochemical parameters shown that glucose, Alanine aminotransferase (AST), Alkaline Phosphatase (AP), cholesterol and triglyceride significantly increased, whereas total protein and creatinine levels were significantly decreased in toxocara infected cats compared to healthy cats. But the serum bilirubin and Blood Urea Nitrogen (BUN) levels were not affected by toxocara infection.