The aim of our study concerns with epidemiological and diagnostic study about prevalence of avian influenza virus in domestic birds depending upon recorded data of veterinarian hospitals in Missan province. so, the study (355) samples of blood and feces were taken from pigeons, (230) sample from chickens, (37) sample of domestic ducks and (9)sample of pet birds in period between (January -2006 to  June- 2006). The results observed there is infected with avian influenza virus subtype A (H5N1) consternated mostly in pigeons 40(11.26%) and also found in domestic ducks 2(5.40%). Amara district was most common infected regions with bird flu in percentage 39(10%), followed by Al-Mshreh 2(2.46%) and Al-Kumit region 1(4.34%).The infection was not recorded in domestic birds in another regions of Missan province.