Effect of growth regulator analogues, pyriproxfen, hydroprene and their combinations with deltamethrin on Boophilus annulatus was investigated. Fully engorged female B. annulatus ticks were collected from naturally infected cattle. The collected ticks were divided into 6 groups of 5 replicates; control untreated, pyriproxfen, pyriproxfen - deltamethrin, hydroprene, hydroprene - deltamethrin, and deltamethrin. Insect growth regulators (IGRs) and deltamethrin were dissolved in DMSO 10% then diluted with distilled water before application. Adult immersion test for the different compounds was applied on engorged female ticks. Reduction of egg mass per female, reproductive index (RI), reproductive efficiency index (REI), and dead tick % in the different groups were estimated. Consequently, the deposited eggs of the different groups were incubated to record the hatching %. Furthermore, egg immersion test of untreated ticks was conducted in the different preparations. Both of pyriproxfen and hydroprene groups had no lethal effect to adult female ticks. Meanwhile, hydroprene and pyriproxfen treated groups showed significant reduction in the egg mass (P ≤ 0.0001) with the control untreated. The highest reduction of egg deposition was estimated in hydroprene - deltamethrin combination groups. There was non-significant difference in hatchability of deposited egg mass of the different groups. Furthermore, with egg immersion test, there was non-significant difference in hatchability of treated eggs including deltamehrin in a comparison with untreated eggs. Hatched larvae in different treatments did not show any abnormal changes. Both of pyriproxfen and hydroprene groups had no lethal effect on adult female ticks in a comparison with deltamethrin groups and deltamethrin-GRAs combination.