This work was carried out to compare between the anticoccidial efficacy of clopidol and garlic powder. Three groups of one day old Hubbard chicks each of 30 birds were used in this study. The 1^st group received only basal ration (control). The second group received clopidol 125 mg/ kg B.W. The third group received garlic powder 5 gram /kg B.W. Birds in all groups were infected with a field stain of Eimeria spp. (50.000 oocysts / bird) at 21 days of age. Mortality rate and clinical signs of coccidiosis were recorded. Also, oocyst count/gm faeces, body weight gain and feed conversion were measured at 7^th, 14^th and 21 ^th day after challenge. Five birds in each group were killed one week post infection and lesion score was determined. Blood samples were collected from birds of each group at the end of experiment for detection of serum levels of AST, ALT, creatinine and uric acid. The obtained data demonstrated that administration of clopidol or garlic powder evoked a significant decrease in mortality rate, oocyst count/gm droppings, lesion score and clinical signs of coccidiosis, compared with infected non treated group. Also, adding of clopidol or garlic powder improved the performance of the birds. The serum level of AST, ALT, createnine and uric acid was decreased by both treatment. It was noticed that  addition of garlic powder induce more prominent effects than clopidol in improving the feed conversion (at 21 day post infection) and serum creatinin level and decreasing the mortality rate.  On the other hand, clopidol treated group had a lower oocysts count/ gm droppings (1^st and 2^nd week post infection) compared with other groups.