The present study was conducted to evaluate the efficacy of both Catechin and Calcium Disodium Ethylene diamine Tetraacetic Acid (CaNa₂EDTA) in treatment of long-term lead toxicity through assessment of some biochemical indices (hematological picture and biochemical parameters). Eighty male albino rats weighting 100-150 g of 10-12 weeks old were randomly divided into 4 groups (20 each). Group 1 was left without any treatment as negative control group. The other three groups (G2, G3 and G4) were exposed to lead acetate in drinking water at a concentration of 30 mg/L for 3 months. G2 was used as positive conrol group. G3 was divided into three subgroups  A, B & C was treated with catechin in drinking water at a concentration of 49 mg/L for 7 days after 1, 2 and 3 month after Pb exposure, respectively. G4 was also divided into three subgroups ( D, E & F ) and treated through IP injection CaNa₂EDTA in a dose of 50 mg/kg body weight, for 5 days after  1, 2 & 3  months of lead exposure. Six rats were taken randomly after 30, 60 and 90 days from negative and positive controls, 37, 67, 97 days from rats treated with catechin and 35, 65 and 95 days from rats treated with CaNa₂EDTA.  Rats were anesthetized with ether and sacrified for blood and tissues collection. Blood samples were collected in vacutainer tubes containing EDTA as anticoagulant for hematological pictures. Brain tissue samples were collected from each rat for the subsequent biochemical parameters (total protein, nitric oxide, lipid peroxidation, glutathione, superoxide dismutase, catalase, glucose 6 phosphatase dehydratase and, acetylcholinestrase activity). The results revealed that administration of catechin or CaNa₂EDTA can minimize any toxic effects on hematological picture & biochemical parameters. Catechin was more effective than CaNa₂EDTA in improvement of Hb concentration, HCT %, MCV, MCH values and NO, LPO parameters but CaNa₂EDTA was more effective than Catechin in improvement of WBCs, lymphocyte, monocyte count and GSH, SOD, CAT activities.