Internal microbial infection may lead to abscesses formation in cattle. This study was conducted on 1500 slaughtered cattle from Mansoura abattoir and Damietta local dairy farms to screen out the presence of internal abscesses. Of 1500 slaughtered cattle, 160 animals (10.67%) were affected with lung abscesses (n=140) (87.5%), lung abscesses with tonsillar involvement (n=3) (1.87%), liver abscesses (n=15) (9.37%), bacterial endocarditis with systemic lodgment of bacterial emboli (n=1) (0.62%) and spinal epidural abscess (n=1) (0.62%). Younger animals less than 1 year were more susceptible. A variety of bacterial species including, Pasteurella multocida (P. multocida) 132 (70.58%), Arcanobacterium pyogenes (A. pyogenes) 30 (16.04%), Pseudomonas aeruginosa 12 (6.41%), Staphylococcus aureus 8 (4.27%) and Streptococcus spp. 5 (2.67%) were isolated. The histopathological changes associated with the internal abscesses formation were described in this study. In conclusion, the frequency of bovine abscesses was the highest in lungs. The most common isolate was P. multocida followed by A. pyogenes.