The aim of the present study was to investigate the prognostic and diagnostic value of cardiac enzymes (creatine kinase-myocardial band (CK-MB), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)) along with a limited lipid profile, including triglycerides (TG), low density lipoproteins (LDL), cholesterol (TCHOL) and high density lipoproteins (HDL), for infection control in goats naturally infected with Corynebacterium pseudotuberculosis (C. pseudotuberculosis). A total of 19 Turkish Hair goats, consisting of 9 healthy goats and 10 goats infected with C. pseudotuberculosis, were selected for the study; all goats were between the ages of 1.5-2 years and resided in a special dairy farm. The housing, nutrition and management conditions were the same for all goats. The selection of animals was based on microbiological analyses. A statistically significant difference was observed in the levels of creatine kinase (CK-MB), alanine aminotransferase, alkaline phosphatase, and low-density lipoprotein (p < 0.05) in goats infected with C. pseudotuberculosis compared to the control group. In conclusion, this study has demonstrated that goats naturally infected with C. pseudotuberculosis have higher levels of cardiac enzymes compared with healthy goats. The prognostic significance of cardiac enzyme levels in goats infected with C. pseudotuberculosis deserves further study.