Extensive use of pesticide has contributed to environmental pollution and adverse health effects to animals and humans. Fipronil (FIP) and emamectin benzoate (EMB), relatively new and widely used insecticides, are potent environmental toxicants. Therefore, the current study aimed to investigate the protective role of bee pollen suspension (BPS) against FIP- and EMB- induced hepato-renal toxicity in rats. Rats were randomly allocated into six equal groups and treated orally, 3 times weekly for 8 weeks; control group (distilled water),BPS group (120 mg/kg), FIP group (9.7 mg/kg), EMB group, (8.8 mg/kg), BPS+FIP group (BPS one h before FIP) and BPS+EMB group (BPS one h before EMB). The results revealed that FIP and EMB significantly increased serum ALT, AST activities; urea and creatinine levels. Also, there were substantial increases in the liver and kidney malondialdehyde level, reduced glutathione content and catalase activity. Moreover, FIP and EMB caused histopathological alterations in liver and kidney tissues. However, pretreatment with BPS one hour either before FIP or EMB administration ameliorated all the biochemical and histopathological changes indicating its antioxidant properties. In conclusion, BPS can be used as a new preventive supplement against toxic insults of FIP and EMB.