Proximal renal tubular acidosis (RTA), a disorder in acid-base balance in the kidney is characterized by loss of bicarbonate ions in urine. One of its causes is the production of free radicals by cisplatin (CP). Therefore, the protective effects of silymarin and bee pollen as antioxidant natural product treatments were evaluated against proximal RTA induced by CP in male albino rats. Rats were divided into 8 groups (7 rats each); control group, cisplatin group, bee pollen group, silymarin group, cisplatin then bee pollen group, cisplatin then silymarin group, bee pollen then cisplatin group and silymarin then cisplatin group. After 12 days (the experiment period), sera were used to determine kidney function parameters (urea, uric acid, and creatinine), protein parameters (total protein, albumin, and globulin), and blood glucose level. While anticoagulant was added to the blood to determine acid-base balance and hematological parameters. Silymarin and bee pollen improved the kidney dysfunction in the CP rats group through decreasing levels of kidney function parameters and increasing levels of serum proteins. They also returned the blood glucose level and the hematological parameters in the CP rats group to the normal values. While the acid-base balance parameters were ameliorated after using silymarin and bee pollen against CP nephrotoxicity. So, we conclude that silymarin and bee pollen can be used to ameliorate the proximal RTA and anemia induced by CP.