Emerging role of Probiotic, Prebiotic and herbal additives in poultry industry should be considered to overcome abuse of antibiotics. The present research accomplished to scrutinize effectiveness of Curcumin, Probiotic and Prebiotic in broilers productivity. Body weight/gain, feed intake, conversion efficacy, hematological analysis and immune-assay were evaluated. 150 chicks were divided into 5 groups, 3 supplemented separately with the mentioned additives in the feed for 5 weeks and the left were fed on basal diet without additives, 4 groups were vaccinated against avian influenza and infectious bursitis. Results exhibited that Curcumin Probiotic and Prebiotic boosted body gain significantly (p < 0.05), at the end of the study 1948.83g, 1950.83g and 1914.03g, respectively, comparing with control 1750.60g and 1772.20g for vaccinated group. Curcumin and Probiotic supplemented groups presented higher packed cell volume (34.09%, 34.08%), red blood cells count (2.49 10⁶/µl, 2.50 10⁶/µl), white blood cells count (31.95 10³/µl, 31.91 10³/µl) and hemoglobin (8.78g/dl, 8.78g/dl) than Prebiotic (32.69%, 2.40 10⁶/µl, 31.45 10³/µl, 8.48dl) and other groups at 3 weeks old. Moreover, ELISA showed that both Curcumin and Probiotic statistically had highest antibody titer for avian influenza (1606.30 and 1592.83), while probiotic had the highest titer 2374.73 for infectious bursitis. Results of current study concluded that the inclusion of Curcumin, Probiotic and Prebiotic not only advanced performance parameters but also improved hematological indices and immunological reaction of broilers. It is advisable to evaluate the cost efficacy to compromise these results.