Necrotic enteritis is a significant problem to the poultry industry all over the world. Little information exists concerning the pathogenesis, immunity or experimental induction of necrotic enteritis in turkeys. Therefore, the present work was designed to develop an experimental model of coccidiosis and necrotic enteritis in turkey for detection of the hematological changes associated with it with trial to overcome using amoxicillin and diclazuril. 40 one day old turkey poults were used for this, divided randomly into 4 equal groups. Gp. (1) left as normal control, gps. (2, 3 and 4) infected experimentally with Eimeria spp, Clostridium perfringens and mixed infection respectively and treatment of groups 2, 3, and 4 by amoxicillin, diclazuril and (amoxicillin+diclazuril) respectively by the appearance of symptoms. The study revealed anemia in gps. 2, 3 and 4, with increase in the platelets count in gps. 2 and 4 and increase in the RBCs osmotic fragility in gps. 3 and 4. In addition to, increase in the total and differential leucocytic count in all infected gps. The amoxicillin and diclazuril had significant improvement in all associated changes.