This study aimed to determine Staph. aureus in raw milk and some milk products and study the correlation between Staph. aureus enterotoxin genes and its ability to resist different types of antibiotics. A total of 120 raw milk, kareish cheese and baladi yoghurt (40 samples, each) were collected from different dairy shops and street peddlers in Assiut city, Egypt and were bacteriologically examined for presence and count of Staph. aureus. The incidences of counted Staph. aureus in raw milk, kareish cheese and baladi yoghurt were 62.5, 27.5 and 0.0%, respectively, with average counts of 3.25 log, 4.13 log and < 1 log cfu/ml, respectively. All the isolated Staph. aureus strains were tested by Multiplex PCR assay for the presence of enterotoxigenic sea, seb, sec and sed genes and 94.44% of the tested strains harbored sea gene and 2.77% were positive for sed gene, while none of the tested strains was positive for seb and sec gene. The recovered organisms exhibited 52.78, 11.11, 77.78, 61.11, 11.11, 36.11, 63.89 and 16.67% resistance towards Oxacillin (Methicillin), Vancomycin, Amoxicillin, Ceftriaxone, Gentamicin, Tetracycline, Erythromycin, and Trimethoprim-Sulfamethoxazole, while, they exhibited 100% sensitivity towards Ciprofloxacin. The tested organisms showed multi-antibiotics resistance percentage of 55.56% and with average resistance index of 0.37. The correlation between Staph. aureus enterotoxin genes and its ability to resist different types of antibiotics revealed that, most of the enterotoxigenic strains were multi-antibiotics resistance and resist simultaneously to Amoxicillin, Ceftriaxone and Erythromycin. All the methicillin resistant Staph. aureus (MRSA) isolates harbored sea gene. The public health hazards of Staph. aureus in milk and its products as well as the suggestive control measures were discussed.