FMRFamide-related peptides are widely disseminated in the mammalian central nervous system. They are involved in abroad pattern biological roles like pain modulation, cardiovascular, and neuroendocrine functions. Although, they have a wide range of functions their source and distribution in different mammalian organs are still not well-known. Numinous studies concerned with FMRFamide-related peptides distribution and biological role in insects and nematodes while the data in mammals are scarce.  In the present study using immunohistochemistry, we detected FMRFamide-related peptides in the ileum, colon, and dorsal root ganglia of adult mice.