This paper investigates the main determinants of the Egyptian brain drain using the augmented gravity model by a long run panel data of eight countries for the period of 1980 to 2013. The fixed effect estimation method is used to estimate the gravity model of migration. The results reveal that the two variables of the gravity model have positive and negative impacts on the Egyptian brain drain. These are compatible with the gravity model theory, but they are insignificant which means that their effects on the Egyptian brain drain are not considered as main factors of migration. However, economic and social factors, low wages and standard of living, spread of corruption and high unemployment rate in Egypt are the main factors of the Egyptian brain drain, as the results signify.