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280978

CORRELATION BETWEEN SERUM MELATONIN LEVEL AND OTHER INDICATORS WITH STAGES OF DIABETIC RETINOPATHY

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Last updated: 05 Jan 2025

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Abstract

Purpose: Diabetic retinopathy is considered the ghost cause of vision deterioration; it is attributed to elevated oxidative stress. Antioxidants, like melatonin, were found to be affected in
diabetic retinopathy. In the present paper, we aim to explore melatonin levels in various stages of
diabetic retinopathy. Method: Patients with diabetic retinopathy were recruited and divided into 3
groups (non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), and
advanced diabetic eye disease). One control group was recruited (diabetics without diabetic
retinopathy). Each participant was subjected to full ophthalmological examination, internal medicine evaluation, fluorescein angiography F/A, as well as optical coherence tomography (OCT) to
classify the stage of diabetic retinopathy. The laboratory evaluation of melatonin, bilirubin, aspartate transferase AST, alanine transferase ALT, fasting plasma glucose FBG, hemoglobin A1c
HA1c, and lipid profile were done. Data were collected and analyzed. Results: Each group < br />includes 60 participants. We found no different sex distribution in the four groups as (P value
=0.77), age in the four groups was as follows 58.35±8.56, 55.77±14.43, 59.3±10.73, 60.98±
7.60 years with (P =0.06). For diabetes-associated variables like duration, fasting glucose
levels, HA1c, and medications (insulin or oral hypoglycemic), we found this result; increased
duration of diabetes with raised levels of FBG, HA1C, and insulin treatment were linked with
severe diabetic retinopathy affection (P value <0.0001). When assessing the plasma melatonin
levels, the mean melatonin levels were decreased significantly with increased severity of diabetic
retinopathy (86.04 ± 2.71, 73.05 ± 6.91, 25.82 ± 2.89, 24.28 ± 2.37 pg/ml) in the studied groups
NDR, NPDR, PDR and advanced diabetic retinopathy with (P-value < 0.0001). Decreased
melatonin could be a risk factor for diabetic retinopathy. As regards total bilirubin, its mean values
decreased significantly with increasing severity of DR (P-value < 0.0001). Conclusion: There
is a relation between the levels of serum melatonin and the severity of diabetic retinopathy.

DOI

10.21608/ejco.2022.280978

Keywords

NPDR, PDR, Melatonin, HA1c, Bilirubin

Authors

First Name

Mahmoud,

Last Name

H.

MiddleName

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Affiliation

Ophthalmology dept., Faculty of Medicine, Sohag, Univ., Egypt

Email

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City

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Orcid

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First Name

Hashim,

Last Name

M.

MiddleName

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Affiliation

Biochemistry dept., Faculty of Medicine, Sohag, Univ., Egypt

Email

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City

-

Orcid

-

First Name

Ahmed,

Last Name

O.

MiddleName

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Affiliation

Internal Medicine dept., Faculty of Medicine, Sohag, Univ., Egypt

Email

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City

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Orcid

-

First Name

Hefny,

Last Name

H.

MiddleName

-

Affiliation

Clinical Pathology dept., Faculty of Medicine, Sohag, Univ., Egypt

Email

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City

-

Orcid

-

First Name

Ali,

Last Name

A.

MiddleName

-

Affiliation

Microbiology and Immunology dept., Faculty of Medicine, Aswan, Univ., Egypt

Email

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City

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Orcid

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First Name

Anbar,

Last Name

M.

MiddleName

-

Affiliation

Ophthalmology dept., Faculty of Medicine, Sohag, Univ., Egypt

Email

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City

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Orcid

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First Name

Awny,

Last Name

I.

MiddleName

-

Affiliation

Ophthalmology dept., Faculty of Medicine, Sohag, Univ., Egypt

Email

-

City

-

Orcid

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Volume

5

Article Issue

2

Related Issue

39047

Issue Date

2022-12-01

Receive Date

2022-11-29

Publish Date

2022-12-01

Page Start

151

Page End

160

Print ISSN

2537-0502

Online ISSN

2537-0944

Article File

EJCO_Volume 5_Issue 2_Pages 151-160.pdf

PDF . 455.4kB

Link

https://ejco.journals.ekb.eg/article_280978.html

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https://ejco.journals.ekb.eg/service?article_code=280978

Order

11

Type

Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations

Type Code

1,824

Publication Type

Journal

Publication Title

Egyptian Journal of Clinical Ophthalmology

Publication Link

https://ejco.journals.ekb.eg/

MainTitle

CORRELATION BETWEEN SERUM MELATONIN LEVEL AND OTHER INDICATORS WITH STAGES OF DIABETIC RETINOPATHY

Details

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Article

Created At

23 Jan 2023