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-Abstract
Aim: To evaluate safety and efficacy of intrastromal injection of voriconazole in treating resistant
fungal corneal ulcer. Patients and methods: A prospective, randomized study performed on
patients with resistant fungal ulcer. Patients were randomly distributed into two groups: Group (A)
included 10 eyes of patient treated with intrastromal injection(s) of voriconazole (50 μg/0.1 ml) and
group (B) included 10 eyes treated with topical voriconazole eye drops 1%. Primary outcome
measure was healing of the fungal ulcer. Secondary outcome measures included duration of
healingin healed cases, any reported complication and the visual outcome. Results: Healing of
fungal ulcer was higher in group A (80%) than in group B (30%) and the difference was statistically
significant. The range of duration of healing in group A was less than that in group B. Ocular trauma
(especially with plant matter) was considered as important risk factor. Conclusion: Voriconazole eye
drops might be considered as effective treatment for resistant fungal ulcer. Delivering voriconazole
by intrastromal injection could raise the healing rate and decreasing the resolution period with
no significant complications.
DOI
10.21608/ejco.2020.162966
Keywords
Intrastromal injection, Fungal ulcer, topical, Voriconazole
Authors
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Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt
Email
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-Orcid
-MiddleName
-Affiliation
Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt
Email
-City
-Orcid
-MiddleName
-Affiliation
Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt
Email
-City
-Orcid
-Link
https://ejco.journals.ekb.eg/article_162966.html
Detail API
https://ejco.journals.ekb.eg/service?article_code=162966
Type
Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations
Publication Title
Egyptian Journal of Clinical Ophthalmology
Publication Link
https://ejco.journals.ekb.eg/
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