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162985

COMPARATIVE STUDY BETWEEN INTRAVITREAL VERSUS SUBTENON INJECTION OF TRIAMCINOLONE ACETONIDE IN MANAGEMENT OF DIABETIC MACULAR OEDEMA

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Last updated: 05 Jan 2025

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Abstract

Purpose: To study the difference in the both safety and efficacy of Intravitreal (IVTA)versus
subtenon (STTA ) triamcinolone acetonide injection as a treatment approach of diabetic macular
edema (DME). Patients and Methods: 50 eyes of 38 diabetic patients diagnosed DME
according to the ETDRS criteria were divided into two groups; each group consists of twenty
five eyes. Group A were injected IVTA with 4 mg (0.1ml). Group B were injected STTA with 40
mg (1ml). Results: In group Awe found that the mean central macular thickness (CMT) reduced
from 465.6 u ± 170.8 u at the baseline level to 285.9 u ± 83.2 u,267.5 u ± 79 u and 288.4u
±169.8uat 1,3 and 6 months post injection respectively. In group B we found that the mean CMT
reduced from 327.65u ± 68.4 u at the baseline level to 273.2 u ± 77.9, 257.8u ± 83.6u and
264.9u ±104.3uat 1.3 and 6 months post injection respectively. In group A we found that the
mean visual acuity (VA) was improved from 0.2 at the baseline to 0.4, 0.3 and 0.4 at 1, 3 and 6
months post injection respectively. In group B we found that the mean VA was improved from
0.3 at the baseline to 0.5, 0.7 and 0.7at 1.3 and 6 months post injection respectively. In group A
we found that the mean intra ocular pressure (IOP)was changed from 16.2 mmHg ±1.2 mmHg
at the baseline to20.9 mmHg ±6.9 mmHg, 17.4 mmHg ±1.6 mm Hg and 17.4 mmHg ±1.6 mmHg
at 1,3 and 6 months post injection respectively. In group B we found that the mean IOP was
changed from15.15mmHg ±1.8 mmHg at the baseline to15.6 mmHg ±1.8 mmHg, 15.8mmHg
±1.8 mmHg and15.7 mmHg ±1.8mmHg at 1.3 and 6 months post injection respectively.
Conclusion: STTA can achieve clinical results comparable to IVTA as regards the reduction of
CMT and the improvement of VA although it achieves this effect somewhat slower.

DOI

10.21608/ejco.2019.162985

Keywords

Diabetic Macular Edema, Intra vitreal triamcinolone acetonide injection, Subtenon triamcinolone acetonide injection

Authors

First Name

Abd El-Rahman,

Last Name

M.

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Affiliation

Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt

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First Name

Abd El-badie,

Last Name

M.

MiddleName

-

Affiliation

Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt

Email

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City

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Orcid

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First Name

Mohamed,

Last Name

A.

MiddleName

-

Affiliation

Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt

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Volume

2

Article Issue

2

Related Issue

23739

Issue Date

2019-12-01

Receive Date

2019-07-27

Publish Date

2019-12-01

Page Start

57

Page End

68

Print ISSN

2537-0502

Online ISSN

2537-0944

Article File

EJCO_Volume 2_Issue 2_Pages 57-68.pdf

PDF . 1.5MB

Link

https://ejco.journals.ekb.eg/article_162985.html

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https://ejco.journals.ekb.eg/service?article_code=162985

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3

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Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations

Type Code

1,824

Publication Type

Journal

Publication Title

Egyptian Journal of Clinical Ophthalmology

Publication Link

https://ejco.journals.ekb.eg/

MainTitle

COMPARATIVE STUDY BETWEEN INTRAVITREAL VERSUS SUBTENON INJECTION OF TRIAMCINOLONE ACETONIDE IN MANAGEMENT OF DIABETIC MACULAR OEDEMA

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Article

Created At

23 Jan 2023