Potato (Solanum tuberosum L.) represents a major globally consumed starchy vegetable crop that possesses a great stature and impact on feeding the world. Several studies have been performed to increase potato production, following different approaches. Biostimulants are magic biomolecules that carry unique traits, allowing them to perfectly fit the mission of augmenting crops' immunity for surviving various provenances of cruel stresses. The current work proposed a modern trend, aiming to take advantage of a research based, new commercially-produced biofertilizer; TAM® (True-Algae-Max), in a trial to evaluate its potentiality for substituting conventional N, P, and K fertilization practice. TAM® is a seaweed extract, distinguished to own an abundancy in biomolecule constituents like; Milbemycin-oxime; 5-Silaspiro [4.4] nona-; Rhodopin; Nonadecane, while also been recognized for its richness in other nutritious biomolecules. Spunta cultivar was treated with three treatments; (1) T1: NPK100%, (2) T2: NPK50%+TAM2.5 mL L-1, and (3) T3: NPK50%+TAM 5 mL L-1, to figure out the best doses for boosting potato yield production, quality, besides biochemical and physiological traits. Resulted data endorsed that TAM® could successfully enhance potato production under field conditions, and intensify its fundamental elements constitution. It is apparently that biomolecules-rich biologically-derived fertilizers would, undoubtedly, stand for novel reliable supplements, in the coming future of producing safe crops, to secure clean global alimentary needs, following environ-mentally friendly managements.