In order to improve productivity of three wheat cultivars as affected by soil salinity conditions by using nano- technological compound (Hypertonic) and humic acid, two field experiments were conducted at the Abess Region, Alexandria Governorate, Egypt, during 2014/2015 and 2015/2016 growing seasons, in split plot design in three replications. The main plots included four salinity alleviated compounds namely; Hpertonic (nano-compound), Humic acid (HA), Hypertonic + HA, and control treatments, while three wheat cultivars (Sakha 93, Sids 12 and Giza 168) was allocated in the sub plot. The results revealed that significant increase was recorded on plant height (cm), spike number/m², spikelets number/spike, grains number/spike, 1000- kernel weight, grain, straw, and biological yields (tons/ha.) as well as harvest index % by using Hypertonic + humic acid in both growing seasons. Sids cultivar recorded the highest mean values for the previous mentioned characters under study. Sowing Sids 12 cultivar under the application of nano- compound and humic acid recorded the highest mean values of yield and its components as compared with Sakha 93 and Giza 168 cultivars under Alexandria conditions.