Coriander (Coriandrum sativum, L.) is an important medicinal herbs worldaride. The objective of this study was to investigate the effect of mineral and bio fertilization on vegetative growth, yield, and chemical composition including essential oil; as well as, major compounds of Coriandrum sativum L. Therefore,   two filed experiments were conducted at the Experimental Farm of the Nubaria station-ELbeharia, Egypt during 2013/2014 and 2014/2015 growing seasons. The experimental design was split plot design with three replicates. Mineral fertilizer levels (control, 50% NPK, 75% NPK and 100% NPK) occupied the main plots. The sub plot was assigned to five bio-fertilizer treatments, i.e.,uninoculation, phosphorein, cerealine, potassomage and mixed bio-fertilizer). Theresultsobtained could be summarized as follows: (1) the addition of mineral fertilizer at rate of 100% resulted in a significant increment in vegetative growth,yield and chemical composition of coriander plants during both seasons, (2) the application of 100%NPK with mixture of biofertilizers (phosphorein +cerealine + potasisomage) was the best combination to obtain the highest mean values of plant height, number of branches/plant, fresh and dry weights of herb/plant, number of umbels/plant, 100-seed weight and seed yield/fed, as well as, oil %, but major compounds resulted fromcombination of 75 % NPK with potassomage and mix of biofertilizers for the coriander were tested in this  study. However, of traits under study increased significantly, due to inoculation treatments over the uninoculation (control) one and the mixture of biofertilizers was the best treatment. This investigation suggests the need for more studies concerning the effect of NPK fertilizer rates and biofertilizers on coriander plants under different environments using different types of soil in order to reach the optimum combination to achieve the best yield.