The present study was carried out to evaluate the effects of foliar application of Saccharomyces cerevisiae (yeast) on vegetative growth of the sole and intercropped maize and peanut plants grown under irrigation with saline water.  This trial was initiated in Soil Salinity & Alkalinity Research Department at Alexandria, Egypt in 2014. A 3-way factorial experiment based on a completely randomized block design, with three replicates was used. The treatments are comprised of three water salinity levels (0, 4, and 8 dS/m), three different cropping system (maize, peanut and maize-peanut intercropped) and 2 foliar yeast applications. Agronomic traits, including plant height, shoot dry weight, cob weight, grain yield, and weight of 100 seeds were recorded. Increasing salinity levels up to 8 dS/m decreased the seeds weight of corn to 56.03% and decreased the grain weight of peanut to 45.06% as compared with control treatment. With respect to the cropping system, intercropping was primitive to induce higher yields than sole plants confirming the positive effect of intercropped corn with peanut. Spraying plants with yeast increased the yield of peanut plants than maize ones.