Field experiment was carried out during May-September, 2015 to study the effect of nitrogen and sulphur application on growth, yield and chemical composition of maize (Zea mays,L) Individual hybrid K 130 cultivar grown under saline soil conditions. The area of each plot was 10.50 m² (3.5 m length x 3 m width), with 5 ridges 60 cm apart and 25 cm between hills. The experiment included 20 treatments which were a combination of four nitrogen rates (0, 30, 60 and 90 kg N/fed) as urea, and five sulphur rates (0, 50, 100, 200 and 300 kg S/fed). The recommended doses of phosphorus (36 kg P₂O₅) as triple superphosphate fertilizer was applied to the soil in a single dose during land preparation. The results showed that the grain yield was increased by relative values of 22.77, 48.38, 75.35 and 104.74% over the control (without S). Also, S application increased significantly the contents of N, P, K and S in leaves of maize. Also nitrogen fertilization significantly affected the grain yield and N, P, K and S contents in leaves of maize.  The highest values of grain yield and nutrients content in leaves were produced at 300 kg S /fed with 90 kg N /fed. on the other hand, the application of S or N decreased the soil pH especially at the highest doses of S or N. in the same time, the available sulphur in soil was increased with increasing the rates of S or N application.