Two field experiments were conducted at the Nubaria Region, Egypt, during 2014/2015 and 2015/2016 growing seasons, in split plot design with three replications to investigate the response of some faba bean (Vicia faba L.) cultivars to mineral and nano-fertilizer applications and their interaction. The main plots were designated for foliar fertilizer with Nano fertilizer (NPK + micronutrients at vegetative stage, flowering stage, and seed filling stage, (vegetative + flowering, (vegetative + filling), (flowering + filling), (vegetative + flowing + filling) stages and Mineral fertilizer(NPK + Micronutrients), while subplot were allocated for three faba bean cultivars (Nubaria 1, Nubaria 2 and Nubaria 3).Significant increase was recorded on plant height (cm), pod length (cm), number of pods/plant, number of seeds/pod, 100- seed weight (g), grain, straw, and biological yield (tons/fed.) as well as harvest index % with fertilizing “Nubaria 2" cultivar by foliar nano- fertilizer at two or three stages (vegetative, flowering or filling) in both growing seasons. Nubaria 2 cultivar recorded the highest mean values for most characters studied.