This investigation was carried out in the Horticulture Research Institute, Agricultural Research Center at El- Montazah, Alex. Egypt, during two successive seasons of 2014 and 2015 to determine the effect of various combinations of fertilizer treatments (NPK, humic and nano NPK) on the growth and chemical composition of Tagetes erecta L., to find out the best combination of these fertilizers that achieve the goal of this study. The experimental design was split- split plot with three replications. Three different NPK fertilizers at three rates each (0 , 50 and 100 mg/l NPK) were allocated in the main plot, humic acid levels assigned in the sub plots (0, 500 and 1000 mg/l) and nano levels were positioned in sub-sub plots (0, 25 and 50 mg/l). The obtained results showed significant differences among the three types of fertilization on the given traits, but  in general the gained results revealed that the applied fertilizers,  at their higher rates, significantly increased plant growth characters (plant height (cm), number of leaves/ plant, inflorescence  diameter, stem diameter, plant leaf area (cm), number of inflorescence/ plant, number of branches/plant, days spanned to first flower emergence, blooming periods, flower durability, chlorophyll content (SPAD), carbohydrates % and carotene contents and N, P and K percentages) in response to the various treatments used in the current study in comparison to that gained from untreated plants (control). Nevertheless, it could be recommended that fertilization of Tagetes erecta with Nano NPK at 50 mg/l and interaction between mineral NPK at 100 mg/l + humic acid at 1000 mg/l + Nano-NPK at 50 mg/l during both growing seasons were the best treatment in producing the highest quality of  growth.