Two field experiments were carried out at theExperimental Farm of the Faculty of Agriculture (Saba- Basha), Alexandria University, Egypt, during 2015/2016 and 2016/2017 seasons, to study three humic acid levels (0, 3 and 6 kg/ha) and  mineral with biofertilization treatments (100% NPK, 75% NPK + rhizobacterin, 75% NPK + phosphorein, 75% NPK + potasiumage, 50 % NPK + rhizobacterin+ phosphorein, 50 % NPK + rhizobacterin+ potasiumage, 50 % NPK + phosphorein+ potasiumage and 25 % NPK + rhizobacterin+ phosphorein + potasiumage) and their interaction on yield, its components and quality of wheat cv. “Sids 12". Split plot design with three replications was used. Humic acid levels were allocated to the main plots, mineral NPK with biofertilization were assigned to sub plots. The obtained results indicated that increasing humic acid up to 6 kg/ha significantly increased most studied characters in both seasons. However, mixed (25 % NPK + rhizobacterin + phosphorein + potasiumage), generally, surpassed other macronutrients with biofertilization treatments for all studied characters in both seasons. Interaction humic acid x biofertilization had significant effect on spike length, number of spikes/m², number of spikelets/spike, 1000- kernel weight (g), grain, straw and biological yields (t/ha) in the two seasons, crude protein, N, P and K percentage, in the first season.