The present study was conducted during two successive seasons 2015 and 2016 on ten years old of Mango (Mangifera indica L.). cv. Keitt cultivar trees grew in El-Bosaily governmental farm at the North West of the Nile Delta, Behira governorate, Egypt. The study was conducted to test the effect of cultivation method and different irrigation levels on growth, yield and fruit quality of mango and also water requirements and water use efficiency.  White screen house and open field (control) were arranged in the main plots and three irrigation levels (50, 75 and 100% of ET₀) were arranged in sub-plots. Results revealed that screen house cultivation gave the highest values of all vegetative growth as shoot length, shoot thickness, leaf area, and chlorophyll concentration index. Also, gave the better fruit set, best yield and yield components as (fruit weight, number of fruits/tree, fruit yield/ tree, gross fruit yield, fruit length, fruit width  and fruit firmness. On the other side, its recorded the highest mean value of  chemical composition (TSS, acidity, TSS/acidity ratio, total sugar, reducing sugar, non-reducing sugar, total carbohydrates and VC) compared to open field cultivation during both experimental season. Furthermore, data showed that 100 % of ET₀ irrigation level significantly increased all studied characters as compared with other treatments. The main advantage of the present study is its potential for saving water and increasing the water productivity of mango.