This experiment was carried out during two successive seasons of (2017 and 2018) on Carnation (Dianthus caryophyllus, L.) cv. "Big Mama" cut flowers  at laboratory of the Plant Production Department, Faculty of Agriculture Saba Basha, Alexandria University, to study the effect of some chemicals and essential oil extracts on keeping quality and vase life of carnation cut flowers. Completely randomized block designed experiment with three replicates treatments for each as follow: control (distillated water), Nano-silver thiosulphate (NST) at (2.5, 5, 7.5 and 10 mg/l), Eucalyptus oil at (25, 50 and 75 mg/l), Mint oil at (25, 50 and 75 mg/l) and 8-hydroxyquinoline sulphate (8-HQS) at (250, 300, 350 and 400 mg/l). Results showed that Nano-silver thiosulphate (NST) at 10 mg/l gave the highest mean values of the physical characters as dry weights (g), floret diameter, vase life, and decrease the number of bacteria, also, Nano-silver thiosulphate (NST) at 10 mg/l gave the best results of chemical compositions as total sugars (%), reducing sugars (%), non-reducing sugars (%),total soluble solids percentage and total carbohydrate percentage  as compared with control treatment, which gave the lowest mean values of the all physical and chemical composition during both seasons.