Two field experiments were carried out at the Experimental Farm, of Sakha Agriculture Research Station, Agriculture Research Centre, Kafr El-sheikh Governorate which is clay soil. These experiments were conducted to study the effect of some weeds control treatments on weeds and potato crop, during the above mentioned dates 2011/12 and 2012/13 winter seasons. Each experiment comprised twelve treatments which were, 1- Sencor 70 % WP (metribuzin 300 g/Fed.), which applied at 5% emergence of potato, 2- Gesagard 50 % SC (prometryn 1.25 L/Fed.), applied at 5% emergence of potato, 3- Stomp 50% EC (pendimethalin 1.7 L/Fed.), applied after planting (AP) and before irrigation, 4- Amex 48% EC (butralin 2.5 L/Fed.), applied post planting, 5-Fusilade forte 15 % EC (fluazifop-p-butyl 1.4 L/Fed.), applied at 30 days after planting (DAP), 6- Sencor followed by Fusilade forte (300 g /1.4 L/Fed.),  7-Gesagard followed by Fusilade forte (1.25/1.4 L/Fed.), 8- Stomp followed by Fusilade forte 1.7/1.4  L/Fed, 9- Amex followed by Fusilade forte 2.5/1.4  L/Fed., 10- hand hoeing twice at 45 and 60 DAP, 11- hand hoeing thrice at 45, 60 and 75 DAP, and 12- Untreated control.          
The results of this obtained showed that the best treatments for controlling weed in potato were hand hoeing twice, hand hoeing thrice and herbicidal combination of Sencor 300g/Fed. + Fusilade forte 1.4 L/Fed. for controlling annual grassy and broadleaved weeds were recorded as of 87.9, 95.6, 81.5% total weeds control in the 2011/12 and 2012/13 winter seasons. Moreover, these treatments increased the number of tuber, average weight of tuber, number of tuber/10 kg, plant height (cm), number of main stems, tuber grading index, tuber shape index, tuber dry matter, starch % and tuber specific gravity compared with untreated check during both seasons of the study.
The research showed that the best treatments to control weeds associated with the potato plants to get the highest yield and quality of potato tubers are hoeing twice or thrice, and four sequenced treatments of Sencor, Stomp, Gesagard and Amex that  followed by Fusilade forte for each.