Two field experiments were carried out at the Experimental Farm of Sakha Agricultural Research Station. Agricultural Reseach Center, Kafr El- Sheikh, Egypt during the two growing seasons 2011 and 2012 to study the response of some physiological, yield characters and seed quality of sunflower "Helianthus annulus, L." C.V. Sakha 53 to mineral organic and biofertilizers. The applied experimental design was randomized complete blocks with four replications.
 
The obtained results could be summarized as follows, (1) The results showed significant differences due to applied 20 kg N/fed + 30 m³ compost on leaf area/plant, dry matter accumulation/plant  at all sampling dates days to full flowering, head diameter, 100- seed weight, seed yield (g)/plant and seed yield (kg)/fed. The highest seed yield/fed viz (2091.29 and 1961.84 kg/fed were obtained by application of 20 kg N/fed + 30 m³ compost during both seasons (2) Application of 20 kg N/fed + 20 m³ compost + Cerealine was the best combination to obtain the highest values of plant height at harvest and head diameter compared with fertilized by 10 kg N/fed. However, oil% and oil yield was increased significantly because of application 20 kg N/fed + 30 m³ compost in both seasons. The present investigation suggests the need for more studies concerning the effect of mineral, organic and bioferlitization as well as applying NPK on sunflower plants under different environmental conditions using different types of soil especially newly reclaimed soil, to reach the optimum combination the achieve to best yield and quality of seed oil content.