The impact of chlorantraniliprole and imidacloprid as technical ingredients and formulated preparation on the enzyme levels in liver and on creatinine and uric acid in kidney of male albino mice (Muss musculus) were determined at certain concentrations (0.1, 0.01 and 0.001 of the LD₅₀). The obtained results of chlorantraniliprole showed that both technical ingredient (95%) and formulated preparation (Coragen^® 20%) reduced the levels of GOT and GPT as liver enzymes and creatinine of kidney. On the other hand, both technical and formulated preparation increased uric acid levels except the formulated chlorantraniliprole at 0.01 of LD₅₀ (2.8 mg/dL).The imidacloprid technical ingredient (95%) and formulated preparation (Admire^® 20%) indicated that GOT and GPT liver enzymes were reduced except at 0.1 and 0.01of imidacloprid (Admire^®).On the other hand, imidacloprid technical ingredient and formulated one increased creatinine and uric acid of kidney except 0.001 concentration. The data obtained for both tested compounds indicated that chlorantraniliprole showed less risk in the liver enzymes and kidney of the male albino mice than imidacloprid did.