Abstract : The effect of different concentrations (2.5 and 5%) of purslane (Portulaca oleraceae, L.) leaves, seeds and mixture on diabetic rats were evaluated. Eighty four rats were used in this study and divided into 8 groups, each group contain 6 rats. Rats were treated by alloxan (150mg/kg B.W) to induced diabetic. Results showed that the lowest glucose levelof treated groups recorded for 2.5% purslane seeds with significant differences. While, the highest glucose levelof treated groups recorded for 5 % purslane seeds with significant differences. The mean values were 163.75 and 131.75, respectively. The lowest GPT and GOT liver enzyme recorded for 2.5% purslane mixture and 2.5% purslane leaves with significant differences. The lowest total cholesterol and triglycerides recorded for 5% purslane mixture  and 5% purslane leaves with significant differences. The highest high density lipoprotein of treated groups recorded for 5 % purslane mixture. While the lowest low density lipoprotein and very low density lipoprotein recorded for 5% purslane mixture and 2.5% purslane seeds with significant differences. The lowest uric acid, urea and creatinine recorded for 5% purslane leaves, 2.5% purslane leaves and 2.5% purslane leaves with significant differences. As conclusion, purslane seeds and leaves showed  highly effect for reduce glucose level, liver functions, kidney functions and improve lipid profile in rats