Background: Methacryloyloxyethyl compounds, including 2-Methacryloyloxyethyl phosphorylcholine (MPC), is now used in dentistry given their biological compatibility and anti-bacterial properties.

Objective: This overview highlights the recent advances methacryloyloxyethyl derivatives have brought into dentistry.

Results: MPC is a biocompatible and hydrophilic biomedical polymer, which is ventured into operative dentistry, orthodontics and endodontics. Its use is always enhanced with another chemical derivative or nanoparticles.
 
Advances in Knowledge: The effect of incorporation of a protein repellent agent into soft lining material on biofilm formation has not been reported. Therefore, this study investigated the reported findings regarding the influence of adding MPC in different ratios to the powder of soft denture liner to benefit from its excellent ability to repel protein adsorption and prevent bacterial adhesion. Adhesive dentistry has improved resin composite with MPC and dimethylaminohexadecyl methacrylate for enhancing the inhibitory effect on secondary caries.