The interoperability between computer applications and medicinal sciences has helped achieve stunning diagnostic advances. In experimental and clinical dentistry, computational integration has been incorporated into basic sciences, orthognathic surgery, oncology, radiology and imaging, prosthodontics, and restorative dentistry. The use of computational applications includes building e-health records, assessing health informatics, knowledge retrieval, modeling and simulation, supporting diagnostic decisions, and robotics. This article provides a bird's eye view of recent breakthroughs that have benefited from computational algorithms and that offer insights into potential future progress in understudied areas of research.