The present study was carried out at Shandaweel Agricultural Research Station (ARC), Sohag Governorate during two successive summer seasons of 2016 and 2017 to study the effect of some weed control treatments on Egyptian cotton productivity in Upper Egypt. Twelve weed control treatments were used including 10 herbicides treatments as follow: T1: Butralin (2.5 L/fed.), T2: Prometryn (1.5 L/fed.), T3: Pendimethalin (1.7 L/fed.), T4: Butralin (2.5 L/fed.) + fluazifop-p-butyl (2 L/fed.), T5: Prometryn (1.5 L/fed.) + Fluazifop-p-butyl (2 L/fed.), T6: Pendimethalin (1.7L/fed.) + Fluazifop-p-butyl (2 L/fed.). T7: Butralin (2.5 L/fed.) + oxyflurofen (0.750 L/fed.), T8: Prometryn (1.5 L/fed.) + Oxyflurofen (0.750 L/fed.), T9: Pendimethalin (1.7 L/fed.) + Oxyflurofen (0.750 L/fed.), T10: Prometryn (1.5 L/fed.) + Pendimethalin (1.7 L/fed.), T11: Hand hoeing thrice and T12: Un-weeded control. A completely randomized block design (RCDB) with four replicates was used in both seasons.Dry weight of grassy, broad-leaved and total weeds (g/m2) at 75 (DAP) were decreased significantly by weed control treatments in both seasons. The lowest dry weight values (favorable) of grassy (1.2 and 7.3 g/m2) were found in T4 and T11 at 2016 and 2017 respectively. While T11 and T10 treatments exhibited the best results of broad-leaved dry weight and total weeds (g/m2) as compared with un-weeded treatment in both seasons.The growth traits were significantly affected by weed control treatments in both seasons. In the 1st season, applying T10 gave the best results on growth traits, while, in the 2nd season applying T7 gave the best results on growth traits as compared with un-weeded control in both seasons.The results revealed that weed control treatments significantly effected on yield and its components in both seasons. In the first season, applying T11 and T10 increased significantly the yield and its components compared with un-weeded control in both seasons. Fiber properties i.e., fiber fineness (F.F), fiber strength (F.S), upper half mean (U.H.M) and uniformity ratio (U.R) were insignificantly affected by weed control treatments in both seasons.In this investigation we can recommended that application of hand hoeing thrice at 18, 30 and 45 day after planting (DAP) or applying prometryn per-emergence 1.5 L/fed., followed by pendimethalin per-emergence 1.7 L/fed, to control total weeds (grassy and broad-leaved weeds), and obtain the highest seed cotton yield (kentar/fed).