The present work illustrates a low cost microcontroller-based system for resistance measurements gas sensing materials. The system is based on a peripheral interface controller (PIC) 16F877A. The designed circuit consists of instrumentation amplifier with multi gain stages controlled by the PIC to amplify the voltage sensor signal. The analog to digital converter (ADC) inside the PIC measures the sensor voltage signal and sends it to the computer. The interface with the circuit, through the RS232 serial port, is managed by a program designed using LabVIEW. Two types of gas sensing materials (lab synthesized nano-particle NiFe2O4 powder and commercial SnO2 powder) have been used to test the system. The sensors' resistance has been measured by the designed system during the exposure to ammonia and water vapor with different concentrations. The reproducibility of the results has been checked out. Therefore, this system can be used by manufacturers and researchers as a quality control system for gas sensing materials.