Objective: To compare the efficacy of two materials on bone formation after surgical removal of mandibular third molars. Materials and Methods: A prospective study was done on thirty patients requiring all mandibular molar extractions in Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Egypt. Patients were selected based on inclusion and exclusion criteria. The procedure was performed under local anesthesia (lignocaine 2% with epinephrine 1:100,000. Mandibular molars were extracted carefully, with minimal soft tissue reflection and without causing any damage to the underlying alveolar bone. The socket was then gently irrigated with normal saline and hemostasis was achieved. Immediately after the extraction, a gelfoam mixed with simvastatin (20 mg simvistatin mixed with normal saline) was placed in the extraction sockets of simvistatin group, a gelfoam mixed with allantoin (20 mg melatonin mixed with normal saline) will be placed in extraction sockets of allantoin group. Afterwards, the sockets were closed with 3-0 vicryl to prevent the carrier from getting displaced and immediate post-operative IOPA was taken for extraction sites. Results: Highest values of bone density were related to simvastatin followed by allantoin. Pain was normal in both simvastatin and allantoin groups but, severe pain was recorded in some cases of control group. Soft tissue healing was better with allantoin and simvastatin than in control group. Conclusion: The two materials are capable of enhancing bone regeneration in the site of extraction.