Objective: to assess the effect of local delivery of lysozyme gel as an adjuvant therapeutic approach in management of gingival and periodontal diseases in terms of clinical and microbiological studies. Patient & Methods: 15 patients with chronic periodontitis were selected All patients were subjected to conventional periodontal therapy (SRP) im one side (control side), moreover; the  other side (applied side) was subjected to sub gingival delivery of  lysozyme gel ( split-mouth design ) into applied and control side And followed up for 4 weeks. .Clinical parameters used in this study included; gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL). These parameters were recorded for all selected patients to provide clinical evaluation of periodontal status at the beginning of the study (baseline), and at the end of the study after 4  weeks. In addition, sub gingival plaque sample were taken before starting the treatment and also at the end of the study after 4 weeks and analyzed for isolation of  p.gingivalis. Results: The applied side show enhancement in the periodontal condition clinically and microbiologically  than control side. Conclusion: Conventional periodontal therapy results is enhanced with using local delivery of lysozyme subgingivally in conjunction.