Background: Dental Implants have changed the face of dentistry over the last 25 years. The clinical replacement of lost natural teeth by osseointegrated implants has represented one of the most significant advances in dentistry. They developed a variable alternative to conventional prosthetic reconstruction of edentulous areas. The goal of modern dentistry is to restore natural contour, function, comfort, aesthetics, speech, and health. Advanced researches in implants designs, materials and techniques have led to predictable success in their application.  Study objective:This study will evaluate the effect of osseointegration and bone formation of biphasic calcium phosphate with platelet rich fibrin (PRF) around dental implants in experimental dogs.  Methods: Eight mongrel dogs will receive dental implants , in which (group B) four dogs  will receive dental implant on the left side with Platelet Rich Fibrin and Biphasic calcium phosphate (study group)  and (group A) four dogs will receive dental implants on the right side with Platelet Rich Fibrin alone (control group). Two dogs will be sacrificed at 2, 4, 6 and 8 weeks one from each group and speciemens will be dissected to be histologically evaluated for new bone formation around implants and osseointegration.  Results: the healing outcome here appeared consistent and bone formation was greater filling almost the whole of the created cavity in group B and the greater part of that cavity in group A with the same superior blood supply in group B than that in group A reflecting great neoangiogenesis. In both groups the formed mass of the new bone exhibited striking appearance of osteointegration with the native bone. The better positive results obtained in association with group B in all of the experimental periods suggest a superior effect of PRF when used in association with BCP as a bone graft than if  PRF used alone. Conclusion: Within the limitations of this experimental study, it can be concluded that PRF in addition to BCP may favor the formation of new bone. The effectiveness of PRF depends not only on its features but also the properties of coadministered grafting material. Key words: PRF, Biphasic Calcium Phosphate, Osseointegration, Implant, Centrifuge.