Objectives: This study was aimed to detect Epidermal Growth Factor Receptor ( EGFR) and Her-2 in OSCC and its surrounding healthy epithelium and identify it's relation to clinical parameters : site, grade, size and nodal metastasis and the possible significance with Disease All Survival ( DAS) and Disease Free Survival ( DFS) for the patients. Materials: In this study 40 samples represents 40 recurrent cases were obtained from Oncology Center Mansoura University (OCMU) during the years from (2010 – 2016).Then markers expression were detected immunohistochemically in tumor area and in healthy epithelium . Results: marked expression for Her-2 were observed in both tumor and healthy epithelium areas, while weak results were noted regarding EGFR in both areas. Despite of the high expression of Her-2, significance were noted only with nodal metastasis and DAS in tumor areas and with nodal metastasis only in area of healthy epithelium. Conclusion:The EGFR expression is present in area of healthy epithelium surrounding tumor in an increased rate. A great increase in Her-2 expression in both tumor and the surrounding area of healthy epithelium was noted, and This was correlated with nodal metastasis and disease all survival. Keywords: EGFR, Her-2, Oral cancer, recurrence.