Aim: This article (literature review) will help dentist practitioner to get information about the bonding of anti-bacterial monomers and fluoride containing self-etch adhesives to dentin and the anti-bacterial effect. Methods: The types of self-etch adhesives systems are revised. Additionally, the bonding mechanism to the dentin and classifications are discussed, also antibacterial effect to cariogenic bacteria are revised. Conclusion:The gross goal of this article is for aid to predict their definitive performance of self-etch adhesives systems, the following conclusions can be assumed: Bond strength of SE adhesives is affected by the adhesive composition (fluoride and MDPB). The SE adhesives systems containing (fluoride and MDPB) have different levels of inhibition zone for the S. mutans.  Keywords: Two-step self-etch adhesives, microshear bond strength and antibacterial effect. Content: 1. Introduction 2. Classification of dental adhesives 2.1. Etch-and-rinse adhesives 2.2. MDP-containing Self-Etch adhesives 2.3. Multi-mode (Universal) adhesives 2.4. Self-Etch Adhesives 3. Microshear Bond Strength 4. Nanoleakage Evaluation