Mohamed R Elshafey¹, Essam T Gaballah^2, Mohamed I Mourad^3,  Rehab Allah I Shahin⁴.   ¹BDS, Faculty of Dentistry, Mansoura University, Egypt. ²Professor and Chairman of Oral Pathology Department, Faculty of  Dentistry, Mansoura University, Egypt. ³ Assistant Professor of Oral Pathology, Faculty of Dentistry, Mansoura  University, Egypt. ⁴ Assistant Professor of Pathology, Faculty of Medicine, Mansoura University, Egypt. Abstract: Objectives:Mucoepidermoid carcinoma (MEC) represents 12-40% among all salivary gland tumors. Insulin-like growth factor-II mRNA-binding protein-3 (IMP3) is an important factor in carcinogenesis of numerous malignant tumors, although its clinical significance in mucoepidermid carcinoma (MEC) remains unknown. The present study investigated the associations between IMP3 expression and the clinicopathological parameters of MEC cases. Methods:The expression of IMP3 in MEC cases was determined immunohistochemically in 40 cases and correlations between IMP3 expression and clinicopathological parameters. Results:The finding of the present study revealed high statistically significant correlation between different histological grades of MEC as well as its clinical stages and IMP3 expression.  Conclusions:These results suggest that IMP3 may be a predictor of prognosis for patients of MEC. Keywords:MEC, IMP3, Immunohistochemistry.