El Hendawy H. A.^[1], Gaballah E. T.²,El Nagdy S. Y.³, Abdelhadi M. Shebl⁴. ¹Teaching Assistant of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Mansoura University,Egypt. ² Professor &head of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Mansoura University,, Egypt. ³Professor of Oral Pathology, Oral pathology Department, Faculty of Dentistry, Mansoura University, Egypt. ⁴Assistant professor of General pathology, General pathology Department, Faculty of Medicine, Mansoura University,Egypt. Abstract: Objectives:Examine the potential role of survivin in head and neck lymphomas by exploring the level of its expression in different clinicopathologic parameters. Methods:Formalin-fixed and paraffin-embedded tissue sections of 43 specimens of head and neck lymphoma were immunohistochemically analyzed forsurvivin expression using Avidin-Biotin complex (ABC) method Results:Survivin was highly expressed in lymphomas with aggressive behavior while low to intermediate level of expression was demonstrated in lymphomas with indolent behavior. High significant differences (p <0.004) were found by Conclusions:Survivin expression in head and neck lymphomas seems to be clinically relevant as it presents a tendency to be less expressed in indolent than aggressive tumors.