The discovery of cancer stem cells (CSCs) has heralded an exciting era in our understanding of squamous cell carcinoma (SCC) with significant implications for diagnosis, prognosis, treatment, and ultimately patient outcomes. LGR5, a CSC-related protein, is targeted by the Wnt-signaling pathway. This study investigated the correlations between the available clinicopathological features of oral SCC and the immunohistochemical expression of LGR-5. The results of this study were LGR5 was expressed in all clinical stages as well as all histological grades of the studied cases with different extents. Statistical analysis revealed significant difference between all clinical stages as well as between all histological types of oral SCC (OSCC) cases in relation to the expression of LGR5. In addition, Spearman's correlation test found highly significant positive correlation between clinical stages and histological grades of studied cases on one hand and expression of LGR5 on the other hand. From these findings, we can conclude that LGR5 might play a role in SCC progression and could be considered as a prognostic indicator in OSCC.   Keywords:LGR5, CSCs, OSCC