Background:Achieving accelerated implant osseointegration could probably result in a more predictable outcome of immediately or early loaded dental implants more predictable. Platelet-rich fibrin (PRF) is frequently used to accelerate soft and hard tissue healing. Purpose: This study was designed to evaluate the effect of platelet rich fibrin on early loading of dental implants. Materialsand Methods:This study involved eight healthy female patients seeking replacement bilaterally missing maxillary premolar teeth. Two or four implants were inserted simultaneously in each patient. Implants placed at the right side were considered as group A, the control group, and were subjected to conventional loading after 3 months. Implants placed at the left side were considered as group B, where PRF was packed into the osteotomy site before implant insertion, and implants were subjected to early loading after one month. Results:None of the implants exhibited mobility. ISQ values recorded at 3, 6 and 12 months of follow up were significantly higher for group A compared to those of group B (P=0.048, P=0.034 and P=0.013 respectively). No statistically significant differences could be found regarding modified bleeding index, pink esthetic score or marginal bone loss. Conclusions:Placement of PRF in the osteotomy site has a positive effect on the process of osseoitegration. The use of PRF results in predictable results when an early loading protocol is to be utilized.   Keywords:dental implants, early loading, conventional loading, implant stabilit, platelet-rich fibrin, resonance frequency analysis, stability.