Aim: Evaluate and compare the effect of application time, agitation and drying air temperature on the resin-dentin shear bond strength of two self-etching adhesive bonding systems (Single bond universal adhesive) and(Xeno V⁺).  Methods: 90 extracted human permanent molars were selected. Each molar was sectioned into 2 halves then embedded into acrylic resin blocks with buccal and lingual surfaces exposed. Flat dentin surface was obtained by wet grinding of enamel. Specimens were randomly divided into two main groups according to the type of adhesive bonding used. Both adhesives were applied as follows:1) 20s or 30 s application time, 2)application with or without agitation, 3) air drying at room temperature(21°c) or at 38°c.Composite resin (Filetk Z250) was applied to the bonded dentin surface using Teflon mold  and light cured. Specimens were  stored in water at room  temperature for 24 hours. Shear bond strength  (SBS)was measured using the universal testing machine . Results: Increasing the time of application led to increasing  SBS of both adhesives, however, it was only significant for Single Bond Universal Adhesive (p = 0.04). There was a significant decrease in SBS of both adhesives when applied without agitation (p≤0.05). Warm air drying (at 38° c) significantly increased SBS of both adhesives (p≤0.05). Conclusions: Increasing the time of application, agitation and warm air drying improves the bonding performance of one-step self-etch adhesive bonding systems.