Aim: The present study aimed to compare the safety and effectiveness of oral midazolam (0.5 mg/kg) and diazepam (0.3 mg/kg) for conscious sedation of pediatric dental patients aged 4 to 6 years old undergoing short dental procedure. Materials and Methods: the study was designed in cross-over manner on 56 healthy dental patients (ASA-Ι), uncooperative (negative category of Frankle behavior scale, as each patient served as his or her control, each patient was randomly sedated once by oral midazolam (0.5 mg/kg) and the second setting by oral diazepam (0.3 mg/kg). The assessment criteria in this study were: duration of visits, the behavioral reaction to drug administration, the taste of the drug, behavioral reaction of local anesthesia administration, vital signs (blood pressure, pulse rate, and oxygen saturation), behavior during treatment, level of sedation, the outcome of treatment, overall behavior, and adverse reactions. Results: No significant difference was found between both drugs as regard the duration of visits. Most of children (80%) didn't cry during drug administration, two children spilled midazolam and refused to complete treatment. Midazolam taste was found to be much bitter than Diazepam. More positive behavioral reaction to local anesthesia was found with midazolam compared to Diazepam. All vital signs were within normal range for both drugs. Midazolam was found to be superior to Diazepam concerning behavior during treatment. Deeper levels of sedation were reported in Midazolam sedation than in Diazepam. Overall behavior and treatment outcome were better in Midazolam sedation. As regard side effects, 2 cases under midazolam sedation exhibited vomiting and dizziness, and 2 cases exhibited hallucination. However no side effects were encountered with diazepam. Conclusions:Oral midazolam (0.5 mg/kg) and Diazepam (0.3 mg/kg) are safe forms of conscious sedation for pediatric dental patients aged 4 to 6 years for short dental procedures, but midazolam was found to be more effective.