Background: Oral malignancy incorporates a gathering of neoplasms influencing any district of the oral cavity, salivary glands and pharyngeal regions. Notwithstanding, this term has a tendency to be utilized conversely with oral squamous cell carcinoma (oscc),which represents the most incessant of every oral neoplasm. It is evaluated that a greater amount of 90% of every oral neoplasm are oscc malignancies. The Bcl-2 protein is the encoding result of Bcl-2 proto-oncogene. It is situated in the mitochondria and may prevent the release of cytochrome c from the mitochondrion to cytoplasm, thereby further inhibiting cell apoptosis. Aim of the study: This study was conducted toscope and find out the possible role of Bcl-2 in the biological behavior of oral squamous cell carcinoma (OSCC). Materials and Methods:    A total of 20 formalin paraffin tissue blocks of OSCC  were included in this study. Hematoxyline and eosine sections were done to confirm diagnosis. OSCC cases were immunohistochemically examined for presence of Bcl-2 using BenchMarkVentanaautostainer and evaluated by 2 separate pathologists using light microscope. Statistical analysis was performed using using chi square test (X2-value), A P value <0.05 was considered statistically significant. Results: There was significant differencebetween grades of OSCC withBcl-2 expression.  Conclusion: Bcl-2can be used to differentiate between grades of OSCC.