Objectives : a patent Mg-6 wt% Zn-0.3 wt% Ca alloy with adequate strength and controllable degradation rate was developed as potential candidate for orthopedic implantation. In vivo osseous regeneration capability of the implant via follow up bone density radiography was evaluated and the effect of its degradation on blood biochemistry was assessed periodically Methods:A total eight cylindrical rods with 15 ± 0.4 mm length and 4 ± 0.2 mm diameter were machined from as-cast Mg-6Zn-0.3Ca alloy and implanted surgically in the femur bone in the mongrel dogs after being anesthetized. Analysis of blood biochemistry and radiographic examination for bone densitometric analysis around the Mg implants were followed up post-operative immediately till the end of the study period (3 months). Results:Biochemical blood analysis for implanted Mg-alloy revealed overall stabilization in electrolytes (Mg, Zn and Ca). Adding to that, kidney and liver function parameters were fallen within the normal range. On the other hand, densitometrical measurements of the newly formed bone around Mg implants revealed that the highest significant bone density was recorded at first and second time intervals (2 & 4 weeks) after implantation when compared with the normal bone. The X-ray image at the second, third, and fourth time intervals showed circumferential periosteal reaction around the Mg-6Zn-0.3Ca alloy rods indicating the formation of new bone. Conclusions:An innovative Mg-6Zn-0.3Ca alloy is suitable for biomedical orthopedic applications because of its controlled biodegradability and adequate strength. It was proven that the investigated Mg- based alloy promotes newly bone formation that had neither adverse effect on blood biochemistry nor kidney and liver functions. Key words: Magnesium alloy, biodegradable, blood analysis,peri-implant bone response.