Asmaa Mahmoud Ali Elshamy*, khayria Ahmed Elkordy**, Doaa Abdallah Farag***,Doaa Shams EldinGhorab**** ^{*Dentist at Ministry of Health **Professor of Oral pathology, Faculty of Dentistry, Mansoura University ***Lecturer of Oral Pathology, Faculty of Dentistry, Mansoura University **** Lecturer of General Pathology, Faculty of Medicine, Mansoura University} Introduction Oral squamous cell carcinoma(OSCC) has a striking global incidence and equally formidable mortality rates. It constitutes a significant proportion, comprising 95%of head and neck cancers^.(1) The risk factors most frequently found associated with OSCC are alcohol and tobacco smoking . Other risk factors as immunodiffenecy, low socio-economic status, HPV infection, diet are well known risk factors as well ^.(3,4) Epithelial-mesenchymal transition (EMT), a fundamental process in embryonic development, has been implicated in cancer progression ^.(5-7)  Several molecules, such as JAM-A and EBV-miR-BART7-3p, have been suggested to regulate EMT via the PI3K/AKT pathway. Particularly, p-Src has been shown to promote the metastasis of pancreatic cancer and HNSCCs by inducing the EMT process ^.(8,9)  Recent reports showed that Src kinase exert multifaceted functions by interacting with tyrosine kinase receptors, such as VEGF and EGFR receptor, or via a variety of intracellular signaling pathways involved in tumor cell growth, cell motility, angiogenesis, and invasion during tumor development ^.(10) Overexpression of Src has been associated with enhanced cancer cell growth,while depletion of Src by antisense oligonucleotides results in reduced cell division ^.(11) Moreover, increased expression of Src kinase has been associated with the development and progression of a number of human malignancies,including pancreatic, colon, ovarian and breast carcinoma . Stabile et al. Demonstrated that the expression of phospho-c-Src is correlated with poor differentiation and lymph node metastases in patients with head and neck squamous cell carcinoma ^.(12,13)